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电刺激或损毁脑的某些部位可引起胃溃疡和/或影响应激引起的胃损伤。脑内的调节肽与胃肠道损伤以及抗损伤过程也有密切关系。据报道,脑室注射促甲状腺素释放激素(TRH)(3～10μg)可加重由消炎痛、5-羟色胺和阿斯匹林等诱发的大鼠胃损伤,脑池或脑室注射TRH(10～30μg)亦加重冷冻加束缚产生的胃损伤。Goto 和Tache 最近报道,不加束缚的大鼠给禁食24小时在室温下脑池注射TRH,可在4小时后诱发胃损伤。TRH 在0.01～1μg 的剂量范围内呈量效关系。另外,一种稳定的TRH 类似物,RX 77368[焦性
Electrical stimulation or destruction of certain parts of the brain can cause gastric ulcers and / or affect stress-induced gastric damage. Regulatory peptides in the brain are also closely related to the injury of the gastrointestinal tract and the process of anti-injury. It has been reported that intracerebroventricular injection of thyrotropin releasing hormone (TRH) (3 to 10 μg) aggravates gastric injury in rats induced by indomethacin, serotonin, and aspirin, and intracerebroventricular injection of TRH (10-30 μg ) Also aggravate the gastric injury caused by freezing and restraining. Goto and Tache recently reported that tethered rats injected with TRH for 24 hours at room temperature at room temperature induced gastric damage after 4 hours. TRH dose-effect relationship within the dose range of 0.01 ~ 1μg. In addition, a stable TRH analogue, RX 77368 [Coke Properties