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由Ｎ－乙酰四氢噻唑－２－硫酮－４－羧酸（［α］２０Ｄ－１０９．８３°），及Ｎ－苯甲酰四氢噻唑－２－硫酮－４－羧酸（［α］２０Ｄ－１１２．２２°），在Ｎ，Ｎ′－二环己基二亚胺（ＤＣＣ）存在下分别与环己胺、苯胺反应得到光学活性产物（Ｒ）－Ｎ－乙酰四氢噻唑－２－硫酮－４－甲酰环己胺（［α］１７Ｄ－７４．５°），及（Ｒ）－Ｎ－苯甲酰四氢噻唑－２－硫酮－４－甲酰苯胺（［α］１９Ｄ－７．０４°）。用量子化学ＰＭ３方法研究了反应物和产物的电子结构。
([[Alpha]] 20D-109.83 [deg.]) And N-benzoyltetrahydrothiazole-2-thione- α] 20D-112.22 °) is reacted with cyclohexylamine and aniline respectively in the presence of N, N’-dicyclohexyldiimine (DCC) to give the optically active product (R) 4-formylcyclohexylamine ([α] 17D-74.5 °), and (R) -N-benzoyltetrahydrothiazole- α] 19D-7.04 °). The electronic structures of reactants and products were studied by quantum chemical method PM3.