作者研究了只有一名患严重中间型β-地中海贫血儿童的核心家庭,母亲是希腊—塞浦路斯人,血液学具有β-地中海贫血的特征,父亲是波兰人,血液学正常。父亲与儿童的β-珠蛋白基因均为具DNA多态性的杂合子。可能β-珠蛋白基因顺序和克隆相同,是由父亲传递给孩子的。儿童β-珠蛋白 The authors studied only one nuclear family of children with severe intermediate β-thalassemia, a Greek-Cypriot mother whose hematology is characterized by β-thalassemia, whose father is Polish and whose hematology is normal. The β-globin genes of both father and child are heterozygous with DNA polymorphisms. It is possible that the β-globin gene sequence is the same as the clone, passed from the father to the child. Children beta-globin