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目的探讨心房颤动(房颤)患者血清高敏C反应蛋白(hs-CRP)变化及与左房内径(LAD)的关系。方法选取房颤患者60例。随机分为持续性房颤组(32例)、阵发性房颤组(28例),另选窦性心律30例患者为对照组。通过心脏超声心动图测量LAD、左心射血分数(LVEF)。采用免疫比浊法测定hs-CRP含量。结果各组hs-CRP和LAD比较。持续性房颤组血清hs-CRP的水平高于阵发性房颤组,差异有统计学意义(P<0.05),阵发性房颤组高于对照组,但差异无统计学意义(P>0.05);同时hs-CRP水平与LAD呈正相关。不同心功能的心房颤动患者hs-CRP随心功能分级加重升高,而LVEF随之下降。结论 hs-CRP在房颤发生及持续中起一定作用,并对预测房产发生、发展有着重要意义。
Objective To investigate the changes of serum high-sensitivity C-reactive protein (hs-CRP) and the relationship with the left atrium diameter (LAD) in patients with atrial fibrillation (AF). Methods A total of 60 patients with atrial fibrillation were selected. Randomly divided into persistent atrial fibrillation group (32 cases), paroxysmal atrial fibrillation group (28 cases), another sinus rhythm 30 cases of patients as control group. LAD and left ventricular ejection fraction (LVEF) were measured by echocardiography. The hs-CRP level was determined by immunoturbidimetry. Results The hs-CRP and LAD in each group were compared. The serum levels of hs-CRP in patients with persistent atrial fibrillation were significantly higher than those in patients with atrial fibrillation (P <0.05), and those in patients with paroxysmal atrial fibrillation were significantly higher than those in controls (P > 0.05). Meanwhile, the level of hs-CRP was positively correlated with LAD. Patients with different cardiac function in patients with atrial fibrillation hs-CRP increased grading with cardiac function increased, while LVEF decreased. Conclusion hs-CRP plays an important role in the occurrence and persistence of atrial fibrillation and is of great significance in predicting the occurrence and development of real estate.