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水溶性是人参皂苷类化合物关键的物理化学性质,也是其药物研发过程中极为重要的问题之一。人参皂苷类药物具有良好的水溶性会有助于药效的发挥和药动学性质的改善,所以其水溶性提升方法的研究引起了人们的关注。通过查阅整理近十年的国内外文献,对人参皂苷类化合物水溶性提升的方法进行了综述,包括成盐、引入极性基团、降低不饱和度、氨基酸酯化、糖基化、二元酸酯化等化学方法,以及制成微球以及自微乳释药系统等物理化学方法,为该类化合物的进一步研发利用提供参考。
Water solubility is one of the key physico-chemical properties of ginsenosides and one of the most important issues in the drug development process. Ginsenosides have good water solubility will help to play a role in pharmacodynamics and pharmacokinetic properties of the improvement, so the water-soluble lifting method of research has aroused people’s attention. The methods of improving the water solubility of ginsenosides are reviewed by consulting the domestic and foreign literatures in recent ten years, including salt formation, introduction of polar groups, reduction of unsaturation, amino acid esterification, glycosylation, binary Acid esterification and other chemical methods, as well as microspheres and self-microemulsion drug delivery systems and other physical and chemical methods for the further research and development of such compounds provide a reference.