目的研究不同病情手足口病患儿免疫球蛋白及补体水平变化,探讨其免疫功能改变及发病机制。方法收集手足口病患儿40例,根据病情分为普通组20例、重症组20例,另选取健康同龄儿童8例作为对照组,用免疫比浊法分别检测免疫球蛋白IgM、IgG、IgA及补体C3、C4水平。结果与对照组相比,重症手足口病患儿IgM、IgG、IgA水平较正常对照组显著下降(P<0.01),但补体C3、C4水平无显著差异(P>0.05)。结论手足口病患儿感染病毒后,体液免疫功能受到影响,导致血清免疫球蛋白IgM、IgG、IgA降低,但对补体C3、C4影响不大。 Objective To study the changes of immunoglobulin and complement levels in children with HFMD in different conditions and to explore the changes of immune function and pathogenesis. Methods Forty children with HFMD were enrolled in this study. According to their condition, they were divided into general group (20 cases) and severe group (20 cases). Eight healthy children of the same age group were selected as control group. Immunoglobulin IgM, IgG, IgA And complement C3, C4 levels. Results Compared with the control group, the levels of IgM, IgG and IgA in patients with severe hand-foot-mouth disease were significantly lower than those in the control group (P <0.01), but there was no significant difference in the levels of complement C3 and C4 (P> 0.05). Conclusion HFMD is affected by humoral immunity in children with HFMD, resulting in decreased serum immunoglobulin IgM, IgG and IgA, but little effect on complement C3 and C4.