184例严重度不一的病毒性肝炎患者血清透明质酸检测结果表明,肝实质受损时间越长,肝功能损害越甚,血清透明质酸含量也见逐步增高,以152.6纳克/毫升((?)±2s)为界鉴别临床诊断为慢性迁延性肝炎和慢性活动性肝炎准确率为90.5%,敏感性为85%,特异性为97.8%,阳性预测率98.1%,阴性预测率为83.0%。血清透明质酸测定对病毒性肝炎的鉴别诊断和判定肝损害的严重程度,具有较大的临床参考价值。 Serum hyaluronic acid in 184 patients with different severity of hepatitis test results showed that the longer the liver parenchyma damage, the more the liver damage, serum hyaluronic acid content also see gradually increased to 152.6 ng / ml ( (?) ± 2s), the accuracy of clinical diagnosis of chronic persistent hepatitis and chronic active hepatitis was 90.5%, the sensitivity was 85%, the specificity was 97.8%, the positive predictive rate was 98.1% and the negative predictive value was 83.0 %. Determination of serum hyaluronic acid for the differential diagnosis of viral hepatitis and determine the severity of liver damage, with a greater clinical reference value.