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【目的】观察银杏叶胶囊对眼压控制的原发性开角型青光眼(POAG)患者视神经的保护作用。【方法】选择本院2012年1月至2014年6月经门诊确诊的 POAG 患者220例，随机分为银杏叶胶囊治疗组(观察组)和安慰剂对照组(对照组)，每组各110例。观察组口服银杏叶胶囊，对照组口服安慰剂胶囊，连续服用6个月。比较观察组和对照组患者的视野指数(平均光敏感度，平均视野缺损和丢失方差)及图形视觉诱发电位在治疗前后的变化。【结果】208例患者完成整个临床试验(银杏叶胶囊治疗组106例，安慰剂对照组102例)。治疗后观察组视野指数及图形视觉诱发电位的振幅显著优于对照组，差异具有统计学意义(均为 P <0.05)。【结论】银杏叶胶囊能明显改善视野指数，促进视觉诱发电位的恢复，对眼压控制的 POAG 的视神经功能具有较好的保护作用。“,”Objective]To evaluate the protective effect of Ginkgo leaf capsule on visual function in primary open-angle glaucoma patients with controlled intraocular pressure.[Methods]The 220 patients diagnosed as primary open-angle glaucoma with medicine-controlled intraocular pressure were enrolled and randomly divided into an observation group and a control group.Patients in the observation group and control group received treatment of Ginkgo leaf capsules and placebo capsules re-spectively for six months.Visual field index (mean sensitivity,mean defect,loss variance)and pattern visual-evoked potential were evaluated before and after treatment in the two groups.[Results]208 patients completed the clinical trial with 106 pa-tients in the observation group and 102 patients in the control group.Mean defect was reduced significantly,and the mean sen-sitivity was improved significantly after 6 months of Gingko leaf treatment when compared to that of before treatment and to that of(both P <0.05),while there is no significant difference in control group.Moreover,the amplitude of pattern visual e-voked potential was significantly improved after Gingko leaf treatment,when compared with that before treatment or that in control group (both P <0.05),and no improvement was investigated in control group.[Conclusion]Gingko leaf capsule could be an effective alternative to protect visual function in primary open-angle glaucoma patients with controlled intraocular pres-sure by improving visual field index and promoting the recovery of the pattern visual evoked potential.