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细胞中微核的出现能反映出染色体畸变的情况,微核率与染色体畸变率之间的相关性显著,因而已将微核率作为测定细胞损伤程度的一种敏感指标。本文运用小鼠骨髓细胞微核试验方法对新型抗炎药尼美舒利进行遗传毒理学测试。以37.5,70,150,300 mg/kg 体重剂量作一次性用药剂量,以37.5 mg/kg 体重剂量间隔24 h 分3 d 连续用药。结果显示,不同剂量及不同给药时间所致微核率为1.9‰～2.3‰,与阴性对照组的差异无显著性(P>0.05)。由此表明,尼美舒利在动物体内无明显致突变性。
The appearance of micronuclei in cells can reflect the situation of chromosome aberration. The correlation between micronucleus rate and chromosome aberration rate is significant. Therefore, micronucleus rate has been used as a sensitive index to determine the degree of cell damage. In this paper, the use of mouse bone marrow micronucleus test method for a new anti-inflammatory drug nimesulide genotoxicity testing. 37.5,70,150,300 mg / kg body weight dose for a single dose, 37.5 mg / kg body weight dose interval of 24 h 3h continuous medication. The results showed that the micronucleus rate was 1.9 ‰ -2.3 ‰ due to different doses and different administration time, and there was no significant difference between the two groups (P> 0.05). This shows that nimesulide in animals without significant mutagenicity.