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2-羟基 - 3-氨基 - 4-苯丁酸 (1 )是制备二肽免疫增强剂类抗癌新药乌苯美司的关键中间体 ,有多种合成方法 ,如 α-氨基苯乙酮法 [1]、α-氨基苯丙醛法 [2 ]、α-氨基苯丁腈法[3] 、苯丁烯酸甲酯法 [4 ] 、苯丙氨酸法 [5]和苹果酸二乙酯法 [6]等。以上各法均存在不同缺点 ,如α-
2-Hydroxy-3-amino-4-phenylbutyric acid (1) is a key intermediate for the preparation of ubiquinone, an anti-cancer drug of the dipeptide immunopotentiator. There are various synthetic methods such as α-aminoacetophenone [1], α-aminophenylaldehyde method [2], α-aminobenzene butyronitrile method [3], methyl crotonate method [4], phenylalanine method [5] Ester method [6] and so on. The above methods have different shortcomings, such as α-