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三氧化二砷(As2O3)对急性早幼粒细胞白血病(APL)治疗中易发生高白细胞血症(高白)严重影响患者早期生存率和生活质量,高白引发脑血管事件致死和中枢浸润屡见报道[1]。As2O3静脉给药产生与维甲酸相似的促分化作用是导致高白的基础[2]临床证实As2O3持续缓慢静脉输注减轻高白[3
Arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) prone to high white blood cell hyperlipidemia (high white) seriously affect the early survival rate and quality of life in patients with high white induced cerebrovascular death and central infiltration are commonly reported [ 1]. As2O3 and retinoic acid intravenous administration similar to the role of promoting differentiation is the basis of high white [2] clinically confirmed As2O3 continuous slow intravenous infusion of high white [3