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目的:探讨银杏叶联合瑞舒伐他汀对糖尿病合并脑梗死的临床疗效。方法:选取2012年5月-2015年5月我院收治的糖尿病合并脑梗死患者98例,根据治疗方法不同分为对照组和研究组,每组49例。对照组采用瑞舒伐他汀钙片治疗,研究组在对照组基础上加用银杏叶提取物治疗。观察并比较两组患者治疗前后血清TNF-α,hs-CRP及血脂水平的变化情况以及临床疗效。结果:与治疗前比较,两组患者治疗后血清TNF-α水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05);与治疗前比较,两组患者治疗后血清hs-CRP水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者TC,LDL-C及TG均低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者HDL-C显著高于治疗前,且研究组高于对照组,差异具有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后NIHSS评分均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论:银杏叶提取物联合瑞舒伐他汀治疗脑梗死合并糖尿病具有显著的临床疗效,能够降低患者血清炎症因子水平,改善患者高血脂状态,值得临床推广应用。
Objective: To investigate the clinical efficacy of Ginkgo biloba combined with rosuvastatin on diabetic patients with cerebral infarction. Methods: From May 2012 to May 2015, 98 cases of diabetic patients with cerebral infarction admitted to our hospital were divided into control group and study group (49 cases in each group) according to different treatment methods. The control group was treated with rosuvastatin calcium, and the study group was treated with ginkgo leaf extract on the basis of the control group. The changes of serum TNF-α, hs-CRP and blood lipid levels before and after treatment and the clinical efficacy were observed and compared between the two groups. Results: Compared with those before treatment, the levels of serum TNF-α decreased after treatment in both groups, and the difference between the two groups was statistically significant (P <0.05). Compared with those before treatment, the levels of serum TNF- hs-CRP levels were lower, and the study group was lower than the control group, the difference was statistically significant (P <0.05); TC, LDL-C and TG were lower in both groups after treatment than before treatment, and the study group was lower than the control (P <0.05). After treatment, HDL-C in two groups was significantly higher than that before treatment, and the study group was higher than the control group, the difference was statistically significant (P <0.05). Compared with those before treatment, NIHSS scores decreased after treatment in both groups, and the study group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Ginkgo biloba extract combined with rosuvastatin in treating cerebral infarction complicated with diabetes has significant clinical curative effect, which can reduce the level of serum inflammatory cytokines and improve the hyperlipemia in patients. It is worthy of clinical application.