论文部分内容阅读
初期多肽相关复合体(nascent polypeptide-associated complex,NAC)是新生肽链从核糖体上延伸出来第一个接触的异二聚体蛋白复合体,从古生菌、酵母到哺乳动物都高度保守。NAC是一个具有多种功能的蛋白,包括保护新生肽链、调控新生肽转位进入内质网和线粒体、肌肉损伤修复等。其α亚基NACA/αNAC(nascent polypeptide-associated complex alpha subunit)主要在转录调控中起作用。此外,NACA还能调控FADD(Fas-associated with death domain protein)所介导的信号转导。在一些病毒性疾病,如乙肝、丙肝和非洲猪瘟中,NACA能与病毒的某些蛋白相互作用,致使机体功能紊乱。在老年痴呆症和唐氏综合征患者脑细胞中,与正常水平相比,NACA表达下调。
The initial nascent polypeptide-associated complex (NAC) is the first contact heterodimeric protein complex in which nascent peptide chains extend from ribosomes, and are highly conserved from archaea, yeast and mammals. NAC is a multifunctional protein that includes protection of nascent peptide chains, regulation of translocation of nascent peptides into the endoplasmic reticulum and mitochondria, and repair of muscle damage. Its α subunit NACA / αNAC (nascent polypeptide-associated complex alpha subunit) mainly plays a role in transcriptional regulation. In addition, NACA can regulate FADD (Fas-associated with death domain protein) mediated signal transduction. In some viral diseases, such as hepatitis B, hepatitis C and African swine fever, NACA can interact with certain proteins of the virus and lead to dysfunction of the body. In Alzheimer’s disease and Down’s syndrome brain cells, NACA expression is down-regulated compared to normal levels.