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采用放射免疫分析法，检测了４７例慢性肾功能衰竭病人终末期血透析治疗前后的血浆心钠素（ＡＮＦ）、泌乳素（ＰＲＬ）以及血清和尿β２－微球蛋白（β２－ＭＧ）的变化。结果发现，透析前各项指标均显著性高于正常人，透析后 ＡＮＦ、尿中β２－ ＭＧ均有明显下降（ Ｐ＜ ０． ０１）， ＰＲＬ、血清β２－ ＭＧ无显著降低（Ｐ＞０．０５）。本文结果提示，慢性肾功能衰竭（ＣＲＦ）病人高ＰＲＬ．血症、高β２－ＭＧ血症经血透析治疗不能纠正，且ＰＲＬ、β２－ＭＧ升高程度可反映肾功能受损程度。
The levels of plasma atrial natriuretic peptide (ANF), prolactin (PRL) and serum and urinary β2-microglobulin (β2-MG) were measured by radioimmunoassay in 47 chronic renal failure patients before and after end-stage hemodialysis Variety. The results showed that all indexes before dialysis were significantly higher than those in normal subjects, ANF and urinary β2-MG after dialysis were significantly decreased (P <0.01), PRL and serum β2-MG were not significantly decreased (P> 0 .05). Our results suggest that patients with chronic renal failure (CRF) have high PRL. Hyperlipoproteinemia and high β2-MG hyperlipidemia can not be corrected by hemodialysis, and the level of PRL and β2-MG can reflect the degree of renal dysfunction.