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[Blythman HE et al:Nature 290(5802):145,1981(英文)] 用化学治疗剂或毒素与抗体的结合物(免疫毒素)攻击肿瘤,在体外试验中获得很大成功。可能由于普通的多克隆抗体不纯以及毒素分子中B分段的结合能引起较强的非特异细胞毒,迄今未用于体内试验。
[Blythman HE et al: Nature 290 (5802): 145, 1981 (English)] Targeting tumors with chemotherapeutic agents or conjugates of toxins and antibodies (immunotoxins) has been a great success in in vitro experiments. It has not been used in in vivo studies to date because of the non-specific cytotoxicity that can be caused by the impure of common polyclonal antibodies and the binding of B fragments in toxin molecules.