本文观察新生儿休克147例。合并多脏器功能衰竭（MOSF）115例，占78．2％。随休克评分增加，血浆儿茶酚胺、肾素、血管紧张素浓度增加，器官损伤数和病死率随之增加，血压则逐渐降低。器官损伤以肺损伤占首位，心功能受损次之，提示在抢救休克过程中积极防治呼吸衰竭和保护心功能是减少休克死亡的重要措施，血压降低非交感神经活性物质分泌衰竭所致。 This article observed 147 cases of neonatal shock. 115 cases were complicated with multiple organ failure (MOSF), accounting for 78.2%. With the increase of shock score, the plasma catecholamines, renin, angiotensin concentration increased, the number of organ damage and mortality increased, while blood pressure decreased. Organ damage to lung injury in the first place, followed by impaired cardiac function, suggesting that the active rescue and prevention of respiratory failure during cardiac arrest and protection of cardiac function is an important measure to reduce the death of shock, blood pressure caused by non-sympathetic nervous activity secretion decline.