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目的探讨血清白蛋白及贫血在慢性阻塞性肺病(COPD)中的原因及预后价值。方法选择住院的急性发作期的COPD患者47例,常规测定身高、体重、血常规和血清白蛋白(ALB),并计算体重指数(BMI)、理想体重百分比(IBW%),根据血清白蛋白结果分为3组,观察不同营养状况对COPD患者的平均住院时间、连续使用抗生素时间及死亡率的影响;并以COPD患者是否贫血分为2组,观察红细胞参数、BMI、平均住院时间及死亡率。结果COPD患者低白蛋白组各指标与白蛋白正常组相比差异有显著性,低白蛋白组体重指数及理想体重百分比均降低(P<0.01),平均住院时间及连续使用抗生素时间延长,死亡率增加;贫血组红细胞各参数均低于非贫血组各参数,COPD的贫血与患者体重指数密切相关(P<0.01),贫血组患者住院时间及死亡率均增加。结论低蛋白血症及贫血在COPD患者中比较常见,营养不良与COPD的住院时间及死亡率密切相关,直接影响患者的预后。
Objective To investigate the causes and prognostic value of serum albumin and anemia in chronic obstructive pulmonary disease (COPD). Methods Forty-seven COPD patients were selected during the acute exacerbation period. Height, weight, blood routine and serum albumin (ALB) were measured routinely. Body mass index (BMI) and ideal body weight percentage (IBW% The patients were divided into 3 groups to observe the effect of different nutritional status on the average length of hospital stay, duration of antibiotic use and mortality in patients with COPD. The patients with COPD were divided into two groups according to their anemia, and the parameters of erythrocyte, BMI, average length of hospital stay and mortality . Results Compared with normal albumin group, the indexes of low albumin group in COPD patients were significantly different. The body mass index and the percentage of ideal body weight of low albumin group were lower (P <0.01), the average length of hospital stay and duration of continuous antibiotics were longer, and death The anemia group had lower erythrocyte parameters than those without anemia group. The anemia of COPD was closely related to the body mass index of patients (P <0.01). The hospitalization time and mortality of patients with anemia were also increased. Conclusions Hypoproteinemia and anemia are more common in patients with COPD. Malnutrition is closely related to hospital stay and mortality in patients with COPD, which directly affects the prognosis of patients.