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目的:通过整理收集含海洋中药的文献,分析古代文献记载的含海洋中药方剂用药规律,了解海洋中药方剂的概况,为挖掘海洋中药用药规律提供数据支持。方法:以海洋中药的药名为检索词,检索《中华医典》、《中华海洋本草》、《中华本草》、《中国药典》、《中药大辞典》等相关文献,筛选含海洋中药方剂,抽取信息并进行标准化处理,构建数据库,初步分析挖掘含海洋中药方剂的相关信息和用药规律。结果:筛选出16 715首含海洋中药的方剂,包含144 014条数据,涉及海洋中药218味,汤剂是最常见的剂型,明、清两朝代的海洋中药方剂数最多;每首方剂中海洋药物出现频率最高的是1-3味,全部由海洋中药组成的方剂占8.065%,其他的都是与陆地中药进行配伍,其中各占一半的达到7.754%,所有方剂中使用频次最高的海洋中药是牡蛎,海洋中药方剂中最常见的陆地中药是甘草和当归。结论:含海洋中药方剂数量庞大,配伍和临床应用具有一定特色,可以为海洋中药的进一步研发和扩大临床应用提供数据基础。
OBJECTIVE: To analyze and summarize the prescriptions of marine traditional Chinese medicine prescriptions contained in ancient literature by collecting and collecting literatures containing marine traditional Chinese medicines, and to understand the general situation of prescriptions of marine traditional Chinese medicines and to provide data support for the excavation of the laws governing the use of traditional Chinese medicines in the oceans. Methods: Taking the names of the Chinese medicine of the sea as the search term, the related literatures such as “Chinese Medical Code”, “Chinese Materia Medica”, “Chinese Materia Medica”, “Chinese Pharmacopoeia” and “Traditional Chinese Medicine Dictionary” Extract information and standardize processing, build a database, preliminary analysis and mining related information containing marine medicine prescription and medication law. Results: 16 715 prescriptions containing marine Chinese medicine were screened, including 144 014 data, covering 218 herbs of marine Chinese medicine. Decoction was the most common dosage form, with the largest number of prescriptions of marine traditional Chinese medicine in the Ming and Qing dynasties. The highest frequency of the drug is 1-3 taste, all the prescriptions composed of marine herbs accounted for 8.065%, the rest are compatibility with terrestrial Chinese medicine, of which each accounted for 7.754% in half, all prescriptions of the highest frequency of marine medicine Is oyster, the most common Chinese herbal medicine in the land of Chinese medicine is licorice and Angelica. Conclusion: The large number of prescriptions containing marine traditional Chinese medicine and the compatibility and clinical application have certain characteristics, which can provide the data basis for further research and development of marine traditional Chinese medicine and to expand clinical application.