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目的观察米索前列醇对预防产后出血的作用。方法将正常单胎头位足月孕阴道分娩513例分为两组研究组260例,胎头娩出后立即舌下含服米索前列醇600μg。对照组253例,在胎儿娩出后肌肉注射催产素20u,采用收集法和面积法测量产后2h内总出血量。结果米索前列醇组较催产素组的第三产程明显缩短(P<0.01),2h内总出血量明显减少(P<0.01),且用药前后两组血压无明显变化。结论米索前列醇对子宫收缩作用快于催产素,能有效地预防产后出血,该药不升高血压,亦适用于妊高征患者。
Objective To observe the effect of misoprostol on postpartum hemorrhage. Methods A total of 513 cases with full-term gestational vaginal delivery in normal single-head fetuses were divided into two groups (study group 260 cases). Sublingual administration of 600 μg misoprostol immediately after birth. The control group of 253 cases, intramuscular injection of oxytocin 20u after fetus delivery, collection and area method to measure the total amount of bleeding within 2h postpartum. Results In the misoprostol group, the third stage of labor was significantly shorter than that of the oxytocin group (P <0.01), and the total amount of bleeding was significantly decreased within 2 hours (P <0.01). No significant changes were found in blood pressure before and after treatment. Conclusion Misoprostol on uterine contraction faster than oxytocin, can effectively prevent postpartum hemorrhage, the drug does not raise blood pressure, also applies to patients with pregnancy induced hypertension.