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目的 探讨基质金属蛋白酶 (MMP2 )及Ⅳ型胶原与胃癌浸润转移的关系。 方法 对2 7例胃癌患者采用临床观察及免疫组化方法观察MMP2 及Ⅳ型胶原在癌组织中的表达。 结果 MMP2 在低分化腺癌、管状腺癌的癌细胞和癌间质中表达率分别为 85 7%、77 7% ,同时有Ⅳ型胶原的破坏 ;在血管淋巴管癌栓及淋巴结转移癌病例中表达率分别为 83 3%、86 7%。 结论 MMP2 的高表达与胃癌浸润和转移有关 ,主要是破坏细胞外间质 ,尤其是Ⅳ型胶原。MMP2 监测可做为判断患者预后的指标
Objective To investigate the relationship between matrix metalloproteinase (MMP2) and type IV collagen and invasion and metastasis of gastric cancer. Methods Clinical observation and immunohistochemical methods were used to observe the expression of MMP2 and type IV collagen in cancer tissues. RESULTS: The expression rates of MMP2 in poorly differentiated adenocarcinoma, tubular adenocarcinoma, and cancer mesenchyme were 85 7% and 77 7%, respectively, and there was destruction of type IV collagen. In vascular lymphangiolei tumor thrombosis and lymph node metastasis The median expression rate was 83 3% and 86 7%, respectively. Conclusion The high expression of MMP2 is related to the infiltration and metastasis of gastric cancer. It mainly destroys the extracellular matrix, especially type IV collagen. MMP2 monitoring can be used as an indicator to determine the prognosis of patients