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当机体局部受到有害刺激会引起防御性炎症反应。炎症初期,白细胞特别是中性粒细胞(PMN)从骨髓或血管壁游离到血液中并聚集到炎症的局部。针对各种刺激,通过活性氧(ROS)的产生和释放蛋白酶,使PMN起到防御作用。但是,如果这些因子过剩或不适当地生成,则有可能引起组织障碍,给机体带来不利影响。如过剩的ROS可使机体内的不饱和脂肪酸氧化,生成过氧化脂质(LPO)引起生物膜障碍。也有人认为,为了保护细胞免遭ROS或LPO的损伤,生物体内存在着超氧化物歧化酶(SOD)、血浆酮蓝蛋白(CP)、铁传递蛋白等抗氧化剂,以维持机体的恒定性。但是,关于这些活性氧的产生系统和消除系统的相互关系,现在
When the body is subjected to harmful stimuli can cause defensive inflammatory response. In the early stages of inflammation, white blood cells, particularly neutrophils (PMNs), dissociate into the bloodstream from the bone marrow or blood vessel wall and accumulate to the site of inflammation. PMN acts as a defensive agent against various stimuli through the production of reactive oxygen species (ROS) and the release of proteases. However, if these factors are excessively or improperly generated, they may cause tissue disorders and adversely affect the body. Such as excess ROS can make the body of unsaturated fatty acids oxidation, lipid peroxidation (LPO) cause biofilm disorders. Some people think that in order to protect cells from damage by ROS or LPO, there are antioxidants such as superoxide dismutase (SOD), plasma ketonetin (CP) and transferrin in the body to maintain the body's stability. However, the relationship between these reactive oxygen species generation systems and elimination systems is now