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目的分析丙种球蛋白治疗小儿手足口病(HFMD)合并病毒性脑炎的临床疗效。方法选取恩平市人民医院2013年7月至2015年7月收治的74例HFMD合并病毒性脑炎患儿为研究对象,按治疗方法分为两组。对照组患儿采取常规对症治疗,观察组在此基础上静脉滴注丙种球蛋白。评定两组治疗效果,观察、比较两组患儿发热、疱疹、呕吐、惊颤、神经系统受累等主要体征与症状恢复时间及住院时间。结果两组治疗总有效率比较,观察组(91.89%)高于对照组(75.68%),差异有统计学意义(P<0.05)。观察组患儿退热时间、疱疹消退时间、呕吐消除时间、惊颤控制时间、神经系统受累时间及住院时间均明显短于对照组,差异有统计学意义(P<0.01)。结论丙种球蛋白治疗小儿HFMD合并病毒性脑炎能迅速改善症状,加快恢复,改善预后,对降低危重症的发生有重要作用,值得临床研究与推广。
Objective To analyze the clinical efficacy of gamma globulin in the treatment of infant hand-foot-mouth disease (HFMD) complicated with viral encephalitis. Methods A total of 74 children with HFMD complicated with viral encephalitis admitted to Enping People’s Hospital from July 2013 to July 2015 were selected as study subjects and divided into two groups according to the treatment methods. Children in the control group were treated with conventional symptomatic treatment, on the basis of which the observation group was given intravenous gamma globulin. The curative effect of the two groups were evaluated. The main symptoms and symptoms such as fever, herpes, vomiting, shivering and nervous system involvement in both groups were observed and compared. The recovery time and hospital stay were also compared. Results The total effective rate of the two groups was significantly higher than that of the control group (91.89% vs 75.68%, P <0.05). The patients in the observation group had significantly shorter antipyretic time, herpes regression time, vomiting elimination time, control time of the nervous system, time of neurological involvement and length of stay in the observation group than in the control group (P <0.01). Conclusion Gamma globulin treatment of children with viral encephalitis HFMD rapid improvement of symptoms, speed up recovery and improve prognosis, reduce the incidence of critically ill plays an important role, worthy of clinical research and promotion.