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目的:观察白藜芦醇对模拟日光照射所致皮肤损伤的防护作用。方法:招募11名健康志愿者,在其背部选取6个非曝光部位。部位1～4分别涂抹白藜芦醇+抗氧化剂、抗氧化剂、白藜芦醇、基质,半小时后予1.5倍最小红斑量的模拟日光照射,部位5仅给予照射而不涂抹检测物质(阳性对照),部位6既不照射亦不涂抹检测物质(阴性对照)。照射前后测量皮肤L值、a*、b*值。结果:在阴性对照部位无红斑,L值和a*值分别为63.76和7.10;在阳性对照和涂抹基质的照光部位均出现明显的红斑,L值显著降至56.10和56.38,a*值显著升至15.55和15.97;涂抹白藜芦醇+抗氧化剂部位红斑轻微,L值降低及a*值升高程度显著低于其他照光部位,L值和a*值分别为59.32和12.96(P<0.05)。结论:白藜芦醇加抗氧化剂可有效防护模拟日光照射引起的急性光损伤。
Objective: To observe the protective effect of resveratrol on simulated skin damage caused by sunlight exposure. METHODS: Eleven healthy volunteers were recruited and six non-exposed sites were selected on the back. Resveratrol + antioxidants, antioxidants, resveratrol, and matrix were applied to sites 1 to 4 and irradiated with simulated daylight 1.5 times the minimum erythema dose after half an hour. Site 5 was irradiated with only the test substance (positive Control), site 6 neither irradiated nor smeared test substance (negative control). The skin L, a*, b* values were measured before and after irradiation. RESULTS: No erythema was observed in the negative control sites. The L values and a* values were 63.76 and 7.10, respectively; significant erythema appeared in the positive control and in the irradiated areas of the smear matrix, with the L values significantly decreasing to 56.10 and 56.38, and the a* value significantly increasing. At 15.55 and 15.97, slight erythema was observed at the resveratrol plus antioxidant sites, and the L value decreased and the a* value was significantly lower than that at other sites. The L and a* values were 59.32 and 12.96, respectively (P<0.05). . CONCLUSION: Resveratrol plus antioxidants can effectively protect against acute photodamage caused by simulated sunlight exposure.