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目的:研究对不能切除的胰腺肿瘤施行术中射频消融治疗的可行性及疗效。方法:对8例手术不能切除的胰腺肿瘤行术中超声引导下射频消融治疗,观察术后并发症、生理生化改变、近期疗效及生存情况。结果:6例患者术后有发热,4例术前疼痛患者有3例术后疼痛得到缓解,7例术后血清淀粉酶升高,所有患者未见术后血糖异常,且肿瘤标志物CA19-9均较术前降低。术后1个月彩超示肿瘤均有不同程度的缩小,瘤内及周边未见血流信号。术后发生胰瘘3例,急性胰腺炎1例,随访12月,死亡2例,6例带瘤存活。结论:对不能手术切除的胰腺肿瘤行术中射频消融治疗是可行的,并有一定的近期临床治疗效果。
Objective: To study the feasibility and efficacy of intraoperative radiofrequency ablation for unresectable pancreatic tumors. Methods: Eight patients with unresectable pancreatic tumors underwent radiofrequency catheter ablation under ultrasound guidance. Postoperative complications, physiological and biochemical changes, short-term efficacy and survival were observed. Results: Postoperative fever occurred in 6 patients. Postoperative pain was alleviated in 3 of 4 patients with preoperative pain. Postoperative serum amylase was elevated in 7 patients. No postoperative blood glucose was observed in all patients. The tumor markers CA19- 9 were lower than preoperative. One month after surgery, the tumors showed different degrees of shrinkage, no signs of blood flow in and around the tumor. Postoperative pancreatic fistula in 3 cases, 1 case of acute pancreatitis, followed up for 12 months, 2 died, 6 cases with tumor survival. Conclusions: Intraoperative radiofrequency ablation of unresectable pancreatic tumors is feasible and has some clinical effects in the near future.