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给予ＴＮＴ５０ｍｇ／ｋｇ，１５０ｍｇ／ｋｇ猕猴持续三个月后，腺垂体的嗜酸性细胞及嗜碱性细胞核异型，胞浆变性，血浆ＡＣＴＨ波动在正常范围，血浆ＬＨ早期下降，睾丸匀浆ＬＨ含量明显减少，肾上腺皮质球状带和网状带细胞肿胀，血浆醛固酮及睾酮含量减少，肾上腺皮质激素生物合成酶（Ｐ４５０ｓｃｃＰ４５０１１βＰ４５０１７α）活性，除Ｐ４５０ｓｃｃ被诱导外均正常。认为ＴＮＴ主要作用在腺垂体，使性激素（ＬＨ）分泌功能受影响，从而影响睾丸间质细胞分泌睾酮减少，ＴＮＴ可能直接损害雄性生殖细胞。
Give TNT50mg / kg, 150mg / kg rhesus monkeys for three months, the pituitary eosinophils and basophils nuclear atypia, cytoplasm degeneration, plasma ACTH fluctuations in the normal range, decreased early plasma LH, testicular homogenate LH content was significantly Decreased, the cortical zone of adrenal cortex and reticular zone cells swelling, decreased plasma aldosterone and testosterone, corticotropin biosynthesis enzyme (P450sccP45011βP45017α) activity, except P450scc was induced outside the normal. It is believed that TNT plays a major role in the pituitary gland and affects the secretion of sex hormone (LH), thus affecting the testosterone secretion in testicular stromal cells. TNT may directly damage male germ cells.