【摘 要】
：
The situation of tuberculosis and M. tuberculosis (MTB) drug resistance is severe in China. Among the MTB isolates, 27.8% were resistant to one primary antitube
【机 构】
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Tuberculosis Research Laboratory,ZHANG Guang-yu,Research Institute of Tuberculosis Control and Preve
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The situation of tuberculosis and M. tuberculosis (MTB) drug resistance is severe in China. Among the MTB isolates, 27.8% were resistant to one primary antituberculosis drug at least. Isoniazid (INH) is one of the first-line anti-TB drugs. The rates of primary resistance and acquired resistance to INH were 11.0% and 31.0%, respectively.1 MTB strains resistance to INH is mainly caused by the alterations in several genes encoding the molecular targets as follows: catalase peroxidase (katG), the enoyl-acyl carrier protein reductase (inhA), the alkyl hydroperoxide reductase (ahpC), beta-ketoacyl-acyl carrier protein synthase (kasA), and NADH dehydrogenase (ndh).2-4 However, the mutations of katG and inhA promoter region, especially in codon 315 of katG, were found in the majority of INH-resistant clinical isolates.
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