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目的 为了探讨绝经后妇女的骨代谢。方法 本文对 37例绝经后妇女及 2 7例正常对照组 ,测定血清 型前胶原羧基末端前肽 (PICP)、 型胶原羧基端吡啶并啉交联肽 (ICTP)、骨钙素 (BGP)、碱性磷酸酶(AL P)、钙 (Ca)、磷 (P)等骨代谢指标。结果 绝经后妇女 组血清 PICP结果明显低于对照组 (P<0 .0 1) ,ICTP结果明显高于对照组 (P<0 .0 0 1) ,BGP明显低于对照组 (P<0 .0 5 )。绝经后妇女 I组 ICTP结果明显高于对照组(P<0 .0 1)。绝经后妇女年龄与血清 PICP、ICTP、BGP具有相关性 ,骨形成指标 PICP、BGP与骨吸收指标 ICTP均有相关性。结论 表明了绝经后妇女骨吸收过程增加较为明显 ,造成骨量丢失
Objective To explore bone metabolism in postmenopausal women. Methods Thirty-seven postmenopausal women and 27 normal controls were enrolled in this study. Serum procollagen carboxyterminal propeptide (PICP), collagen type CTP, BGP, Alkaline phosphatase (ALP), calcium (Ca), phosphorus (P) and other indicators of bone metabolism. Results The results of PICP in postmenopausal women were significantly lower than those in control group (P <0.01). The ICTP results were significantly higher in the postmenopausal women than those in the control group (P <0. 0 5). The post-menopausal women in group I ICTP results were significantly higher than the control group (P <0. The age of postmenopausal women was correlated with serum PICP, ICTP and BGP. The bone formation index PICP and BGP were correlated with bone resorption index ICTP. The conclusion shows that the increase of bone resorption process in postmenopausal women is more obvious, resulting in the loss of bone mass