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目的探讨中枢神经系统医院感染患者心肌酶以及一氧化氮(NO)水平的变化,为中枢神经系统感染早期诊断、利于改善预后提供参考依据。方法选取2011年4月-2013年12月中枢神经系统医院感染患者69例作为观察组,同期健康体检人员70名作为对照组,对两组人员血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)、一氧化氮(NO)以及一氧化氮合成酶(NOS)水平进行检测并比较,所有数据采用SPSS13.0软件进行统计分析。结果观察组患者的CK、CK-MB、LDH及α-HBDH明显高于对照组,差异有统计学意义(P<0.05);患者NO及NOS观察组分别为(56.38±5.09)μmol/L和(58.22±4.13)U/ml,对照组分别为(41.13±4.33)μmol/L和(29.56±3.01)U/ml,两组比较差异有统计学意义(P<0.05)。结论通过检测血清心肌酶和NO水平对中枢神经系统感染进行早期诊断和判断严重程度,从而尽早采取措施进行治疗,以改善患者的预后。
Objective To investigate the changes of myocardial enzymes and nitric oxide (NO) levels in patients with nosocomial infection of the central nervous system (CNN) for the early diagnosis of central nervous system infection and to provide a reference for improving prognosis. Methods From April 2011 to December 2013, 69 patients with central nervous system nosocomial infection were selected as the observation group and 70 healthy people as control group during the same period. Serum creatine kinase (CK), creatine kinase (CK-MB), lactate dehydrogenase (LDH), a-hydroxybutyrate dehydrogenase (α-HBDH), nitric oxide (NO) and nitric oxide synthase (NOS) All data using SPSS13.0 software for statistical analysis. Results The CK, CK-MB, LDH and α-HBDH in the observation group were significantly higher than those in the control group (P <0.05). The levels of NO and NOS in the observation group were (56.38 ± 5.09) μmol / L and (58.22 ± 4.13) U / ml in the control group and (41.13 ± 4.33) μmol / L and (29.56 ± 3.01) U / ml in the control group respectively. There was significant difference between the two groups (P <0.05). Conclusion Early diagnosis and determination of CNS infection by detecting serum myocardial enzymes and NO levels may lead to early treatment and improvement of patients’ prognosis.