１９８２年Ｍｅｓｕｌａｍ首次报道慢性进行性失语症（Ｓｌｏｗｌｙｐｒｏｇｒｅｓｓｉｖｅａｐｈａｓｉａ，ＳＰＡ），认为该病特点为慢性进行性失语，无智力、行为障碍，神经系统无阳性体征，神经影像学为脑外侧裂周局部萎缩［１］。此后陆续散在的报道均认为，此病无智力障 Mesulam first reported chronic progressive aphasia (SPA) in 1982 and was characterized by chronic progressive aphasia without mental retardation and behavioral disorders, with no neurological signs in the nervous system, and neuroimaging was a partial atrophy of the lateral cerebral fissure [1 ]. Since then there are scattered reports that the disease without mental retardation