Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs(ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity,its underlying mechanisms and alternative therapies for the same. There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of Several natural and synthetic compounds in minimizing this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ​​ATD-induced hepatotoxicity, its underlying mechanisms and alternative therapies for the same.