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目的研究西洋参花蕾中非皂苷类化学成分。方法应用大孔树脂柱色谱、正相硅胶柱色谱等手段对西洋参花蕾中非皂苷类成分进行分离纯化,并通过1H-NMR、13C-NMR、ESI-MS、HMBC、HMQC等波谱数据鉴定化合物结构。结果分离得到了3个核苷类化合物和1个木脂素类化合物,分别鉴定为脱氧尿苷(2′-deoxyuridine,1)、脱氧胸苷(2′-deoxythymidine,2)、阿糖腺苷(vidarabine,3)和松脂素(pinoresinol,4)。结论化合物1-4均为首次从人参属植物中分离得到。
Objective To study the non-saponin chemical constituents of American ginseng flower buds. Methods The non-saponins in the flower buds of Panax quinquefolium were isolated and purified by macroporous resin column chromatography and normal-phase silica gel column chromatography. The structures of the compounds were identified by 1H-NMR, 13C-NMR, ESI-MS, HMBC and HMQC. . Results Three nucleoside compounds and one lignan compound were isolated and identified as 2’-deoxyuridine (1), 2’-deoxythymidine (2), adenosine arabinoside. (vidarabine, 3) and pinoresinol (4). Conclusion Compounds 1-4 were isolated from Panax species for the first time.