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目的分析北京市平谷区恙虫病流行病学特点以及临床特征,了解恙虫病在该地区的分布状况,以便进行深一步研究。方法对该组病例进行回顾性调查,采用描述流行病学方法分析该次调查的恙虫病流行特点。结果自2009年10月3—22日共发生恙虫病15例,男性8例,女性7例;平均发病年龄为51.6岁。其中农民10例,工人5例。15个病例均有发热症状,以稽留热为主。有溃疡焦痂症状者14例,占发病数的93.3%。在应用间接免疫荧光试验进行单份血清检测后,1例患者IgM抗体滴度≥1:32,14例IgG抗体滴度≥1:64;在应用PCR检测恙虫病东方体特异基因片段的结果中,呈阳性反应者10例。首诊误诊率为93.3%。结论该地区恙虫病的流行是典型的秋季型恙虫病,症状复杂,早期误诊率较高。同时,在该地区可能存在恙虫病自然疫源地,应对疫源地范围进行深一步的监测和研究。
Objective To analyze the epidemiological characteristics and clinical features of scrub typhus in Pinggu District of Beijing and to understand the distribution of scrub typhus in the area in order to conduct further research. Methods A retrospective study was conducted in this group of patients and epidemiological characteristics of scrub typhus were analyzed by using descriptive epidemiological method. Results From October 3-22, 2009, there were 15 tsutsugamushi diseases, including 8 males and 7 females. The average age of onset was 51.6 years. Among them, 10 were farmers and 5 were workers. 15 cases have fever symptoms, mainly to retain the heat. There are 14 cases of ulcer eschar symptoms, accounting for 93.3% of the number of cases. In the indirect immunofluorescence assay for single sera, one patient had IgM antibody titers ≥1: 32 and 14 IgG antibody titers ≥1: 64. In the PCR-based PCR-based analysis of the results of oriental specific fragments of tsutsugamushi , Positive in 10 cases. The first visit misdiagnosis rate was 93.3%. Conclusion The prevalence of scrub typhus in this area is a typical fall scrub typhus, with complicated symptoms and high misdiagnosis rate. In the meantime, there may be a natural foci of tsutsugamushi disease in the area and further monitoring and research should be conducted on the scope of the foci.