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丁丙诺啡：一种新型阿片维持剂？丁丙诺啡是蒂巴因的衍生物，对μ阿片受体具有部分激动活性。它在体内通过Ｎ位脱烷基和共轭作用在体内代谢，半衰期为３－５ｈ，分布容积为９７－１８８Ｌ。丁丙诺啡体内清除率较高，在肝脏有首过效应。舌下含服后的系统利用度约为５５％（...
Buprenorphine: A New Opiate Rejuvenator? Buprenorphine is a derivative of thebaine and has partial agonistic activity on mu opioid receptors. It is metabolized in vivo by N-dealkylation and conjugation with a half-life of 3-5h and a distribution volume of 97-188L. Buprenorphine high clearance rate in the liver has the first pass effect. Sublingual service system utilization after about 55% (...