实验研究工作认为前列腺素类对肾绞痛的疼痛产生有重要作用,许多研究已表明抗前列腺素类在处治这种病情是很有价值的。现已进行试验确定一种可能的前列腺素合成酶抑制剂双氯灭酸钠与治疗急性肾绞痛常用的麻醉性镇痛药杜冷丁的相对疗效和耐受性。 58名病人诊断为急性肾绞痛在严重疼痛时送入急诊部接受双盲研究。每名病人给予杜冷丁(100mg肌肉注射)或双氯灭酸钠(75mg肌肉注射)。对 Experimental studies suggest that prostaglandins play an important role in the pain of renal colic. Many studies have shown that anti-prostanoids are of great value in the treatment of this condition. A trial has now been conducted to determine the relative efficacy and tolerability of a prostaglandin synthetase inhibitor dicloate in combination with dolantin, a nausea drug commonly used in the treatment of acute renal colic. Fifty-eight patients were diagnosed with acute renal colic and were admitted to the emergency department for double-blind studies in the event of severe pain. Dulcintine (100 mg intramuscular injection) or diclofenac sodium (75 mg intramuscular injection) was administered to each patient. Correct