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目的 探讨肝素配伍小剂量阿斯匹林治疗妊娠合并原发性抗磷脂综合征 (antiphospho lipidsyndrome ,APS)对妊娠结局的影响。 方法 回顾性分析 32 0例不明原因的反复妊娠丢失的妇女 ,排除其它常见原因后 ,进行抗心磷脂抗体 (anticardiolipinantibody ,aCL)IgG、IgM测定 ,36例阳性者接受肝素配伍小剂量阿斯匹林治疗。 结果 36例患者中 34例获活婴 ,死胎 1例 ,流产 1例 ,妊娠成功率为 94 .4 % ,孕周 (35 .7± 3.2 )周。新生儿体重为 (2 96 0± 4 5 8)g ,较同期相同孕周新生儿体重(2 6 84± 32 4 ) g明显增加 (P <0 .0 5 )。 结论 肝素配伍小剂量阿斯匹林治疗APS可明显改善妊娠结局 ,为治疗妊娠合并原发性APS的有效方法。
Objective To investigate the effect of heparin combined with low-dose aspirin on pregnancy outcome in pregnancy complicated with primary antiphospholipid syndrome (APS). Methods A retrospective analysis of 320 cases of women with unexplained repeated pregnancy loss, excluding other common causes, anticardiolipin antibody (aCL) IgG, IgM determination, 36 patients were positive with heparin and low-dose aspirin treatment. Results Of the 36 patients, 34 were alive, 1 died of stillbirth, and 1 had abortion. The pregnancy success rate was 94.4% and gestational age was 35.7 ± 3.2 weeks. The newborn’s body weight was (2 96 0 ± 45 58) g, which was significantly higher than that of the same gestational week (2 6 84 ± 32 4) g (P 0 05). Conclusion Heparin with low-dose aspirin in the treatment of APS can significantly improve the pregnancy outcome, and is an effective method for the treatment of primary APS during pregnancy.