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目的:探讨α-连接素在宫颈鳞癌组织中的表达及其意义。方法:采用免疫组织化学方法检测10例正常宫颈、15例宫颈上皮内瘤变及48例宫颈鳞癌活检和术后组织标本的α-连接素表达,并进行相关分析。结果:正常宫颈、宫颈上皮内瘤变和宫颈鳞癌组织α-连接素表达差异有统计学意义(P<0.01);宫颈鳞癌不同病理分级、淋巴结转移状况与α-连接素表达程度差异有统计学意义;α-连接素表达与患者年龄、肿瘤大小、临床分期及患者血清鳞状细胞癌抗原水平差异无统计学意义(P>0.05)。结论:α-连接素在宫颈鳞癌中表达减弱,可能在宫颈鳞癌的发生、发展中起抑制作用,检测α-连接素表达有利于指导临床诊断及判断预后。
Objective: To investigate the expression of α-catenin in cervical squamous cell carcinoma and its significance. Methods: The expression of α-catenin in 10 cases of normal cervix, 15 cases of cervical intraepithelial neoplasia and 48 cases of cervical squamous cell carcinoma biopsy and postoperative tissue specimens were detected by immunohistochemistry and analyzed. Results: There were significant differences in the expression of α-catenin between normal cervix, cervical intraepithelial neoplasia and cervical squamous cell carcinoma (P <0.01). The differences in the pathological grade, lymph node metastasis and α-catenin expression between cervical squamous cell carcinoma Statistically significant difference was not found between α-catenin expression and patient’s age, tumor size, clinical stage and patient’s serum squamous cell carcinoma antigen level (P> 0.05). Conclusion: The expression of α-catenin in squamous cell carcinoma of the cervix is weakened, which may play an inhibitory role in the occurrence and development of cervical squamous cell carcinoma. Detecting α-catenin expression is helpful to guide the clinical diagnosis and prognosis.