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恶性肿瘤的发生、发展和转移均依赖于血管生成，以新生血管为靶点，抑制肿瘤血管生成已成为近年来癌症治疗的新策略。肿瘤血管生成是一个多步骤的复杂过程，并由多种血管生成因子和血管生成抑制因子共同调控所决定的。在血管生成抑制因子中，血管抑素（angiostatin）及内皮抑素
The occurrence, development and metastasis of malignant tumors are all dependent on angiogenesis. Targeting new blood vessels, inhibiting tumor angiogenesis has become a new strategy for cancer treatment in recent years. Tumor angiogenesis is a multi-step complex process that is determined by a combination of multiple angiogenic factors and angiogenesis inhibitors. Among angiogenesis inhibitors, angiostatin and endostatin