Spontaneous rupture of the liver is a rare condition with serious consequences,if not recognized and treated in time. It has been reported as a complication of several disorders,including benign or malignant liver tumors,connective tissue disease,infiltrating liver disease,preeclampsia,and post anticoagulant therapy. We report a case of spontaneous rupture of liver in a non-cirrhotic,chronic hepatitis B and D patient presenting with acute hemoperitoneum and shock. The subcapsular hematoma and rupture of liver were documented by image studies. The patients’ condition gradually stabilized after fluid resuscitation. The reported case and literature review suggest that spontaneous rupture of liver must be considered in a differential diagnosis of acute hemoperitoneum. A high index of suspicion and early diagnosis with imaging are critically important. Spontaneous rupture of the liver is a rare condition with serious consequences, if not recognized and treated in time. post anticoagulant therapy. We report a case of spontaneous rupture of liver in a non-cirrhotic, chronic hepatitis B and D patient presenting with acute hemoperitoneum and shock. The subcapsular hematoma and rupture of liver were documented by image studies. The patients’ condition. The reported case and literature review suggest that spontaneous rupture of liver must be considered in a differential diagnosis of acute hemoperitoneum. A high index of suspicion and early diagnosis with imaging are critically important.