多发性硬化症是中枢神经系统脱髓鞘疾病,其特点为病灶多发,病程常缓解和复发,近年来在我国有发病率上升趋势[1]。由于该病病程长,易反复发作,受损部位多发,神经功能缺损影响大,因此使患者身体受到巨大损害,经济负担加重,心理压力大,易引起情感障碍,尤以发病后抑郁状态最多见[2]。我科采用西酞普兰治疗多发性硬化伴发抑郁患者31例,效果满意,现报道如下。 Multiple sclerosis is a demyelinating disease of the central nervous system, which is characterized by multiple lesions, the course of disease often remission and relapse, in recent years there is an upward trend in our incidence [1]. Because of the long course of the disease, easy to recurrent, multiple lesions, neurological deficits, so that the patient suffered huge damage to the body, increased financial burden, psychological stress, easy to cause affective disorders, especially after the onset of depression, the most common [2]. 31 cases of citalopram treatment of patients with multiple sclerosis with depression in our department, with satisfactory results, are reported below.