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目的 探讨醋酸甲孕酮 (DMPA)避孕针对子宫内膜异位症 (内异症 )治疗的临床效果。方法 72例经病理组织检查确诊为内异症 (2 9例子宫腺肌病、4 3例卵巢巧克力囊肿 )患者及 30例正常避孕者 ,均于用药前及用药满 1年用B超测量子宫、卵巢各径线的半径值 ,抽取前臂肘正中静脉血 ,用放射免疫法测定性激素 (促卵泡激素、黄体生成素、雌二醇、孕酮、催乳激素 )水平 ,用药期间用月经卡记录月经情况。结果 用药后所有痛经者 ,疼痛明显减轻或消失 ,最主要的副反应为月经变化 ,用药前与用药满 1年 ,激素水平变化不大 ,仍保持在卵泡早期低水平状态 ,无显著性差异 (P >0 .0 5 ) ,巧克力囊肿患者治疗后卵巢体积缩小 ,有显著性差异 (P <0 .0 5 )。结论 注射DMPA对减轻内异症相关症状是一种有效的治疗措施
Objective To investigate the clinical effect of DMPA contraceptives on the treatment of endometriosis (endometriosis). Methods Totally 72 patients with endometriosis (29 cases of adenomyosis and 43 cases of ovarian chocolate cyst) were diagnosed by pathological examination and 30 cases of normal contraception. All patients were diagnosed by ultrasound B-mode ultrasonography , Ovarian radial diameter of each line, the median elbow extraction forearm venous blood, radioimmunoassay determination of sex hormones (follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin) levels, menstrual card recording menstrual period Happening. Results All dysmenorrhea after treatment, pain significantly reduced or disappeared, the most important side effects of menstrual changes, before treatment and medication for 1 years, hormone levels did not change much, still remain in the follicular early low-level state, no significant difference P> 0.05), the ovarian volume of chocolate cyst decreased after treatment, there was a significant difference (P <0.05). Conclusions Injection of DMPA is an effective treatment to reduce the symptoms related to endometriosis