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目的观察IgA肾病合并代谢综合征(MS)患者生活方式干预的临床效果。方法选择我科2007-2011年确诊IgA肾病合并代谢综合征患者62例,随机分为2组,研究组为生活方式干预(运动锻炼、合理饮食、戒烟限酒)合并药物治疗组,对照组为单用药物治疗组6,个月后比较两组代谢综合征相关的参数及24小时尿蛋白定量、肾功能等。结果研究组生活方式干预6个月后,代谢综合征相关危险因素,如肥胖、高血压、高血糖、高甘油三酯、高尿酸均有明显改善(,P<0.01,或P<0.05)。研究组与对照组治疗后比较肾功能明显好转,24小时尿蛋白定量明显降低(P<0.05)。结论对IgA肾病合并代谢综合征患者应用活方式干预联合药物治疗,可有效控制病情的进展。
Objective To observe the clinical effect of lifestyle intervention in IgA nephropathy with metabolic syndrome (MS). Methods Sixty-two patients with IgA nephropathy and metabolic syndrome diagnosed in our department from 2007 to 2011 were randomly divided into two groups. The study group was treated with lifestyle intervention (exercise, reasonable diet, smoking cessation and alcohol restriction), and the control group was Single-drug treatment group 6, months after the comparison of metabolic syndrome-related parameters and 24-hour urinary protein, renal function and so on. Results Six months after lifestyle intervention, the risk factors associated with metabolic syndrome such as obesity, hypertension, hyperglycemia, hypertriglyceridemia and hyperuricemia were significantly improved (P <0.01 or P <0.05). Compared with the control group, the renal function of the study group and the control group was significantly improved, and the urinary protein in 24 hours was significantly decreased (P <0.05). Conclusion IgA nephropathy patients with metabolic syndrome combined with live treatment interventions can effectively control the progression of the disease.