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目的 探讨白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)在慢性阻塞性肺疾病(COPD)发病机理中的作用。方法 采30例COPD急性发作期及缓解期患者血清,应用放射免疫法和液相竞争法分别测血清IL-8及TNF-α水平。结果 COPD患者急性发作期IL-8及TNF-α水平分别为:(1 .9608±2.0304)ng/L、(4 .6170±2 .2745)ng/L;缓解期IL-8及TNF-α水平分别为(1 6648±1 6786)ng/L、(3 8916±2 0820)ng/L;正常对照组IL-8及TNF-α水平分别为:(0. 3738±0 .1448)ng/L,(0 .7056±0. 5223)ng/L,急性发作期和缓解期IL-8 及TNF-α水平明显高于正常对照组(P<0 01),且急性发作期IL-8 及TNF-α水平又高于缓解期(P<0. 05)。结论 IL-8、TNF-α共同参与COPD气道炎症的形成,在COPD形成过程中可能起重要作用。
Objective To investigate the role of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods Seventy patients with acute exacerbation of COPD and remission serum were collected. Serum IL-8 and TNF-α levels were measured by radioimmunoassay and liquid-phase competition. Results The levels of IL-8 and TNF-α in acute exacerbation of COPD were (1.9660 ± 2.0304) ng / L and (4.6170 ± 2.2745) ng / L, respectively. The levels of IL-8 and TNF-α in the normal control group were (0.3738 ± 0.1448) ng / L, (3 8916 ± 2880) ng / L, L, (0.7056 ± 0.5223) ng / L, IL-8 and TNF-α levels in acute and remission stage were significantly higher than those in normal control group (P <0.01) The level of TNF-α was higher than that of remission (P <0.05). Conclusion IL-8 and TNF-α participate in the formation of airway inflammation in COPD, which may play an important role in the process of COPD.