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目的 探讨难治性肾病综合征（RNS）患者血凝学指标的变化。方法 31例RNS为实验组，另设31例正常对照。两组均检测第Ⅷ因子相关抗原（ⅧR:Ag）、纤维蛋白原（Fbg）、抗凝血酶Ⅲ（AT-Ⅲ）、纤溶酶原（Plg）、白陶土部分凝血活酶时间（APTT）、凝血酶原时间（PT）及血小板聚集试验（PAgT）的变化。结果：ⅧR:Ag、Fbg、PAgT与正常组比较显著增高，AT-Ⅲ、Plg与正常组比较显著降低，APTT时间显著缩短，PT与正常对照组比较无显著性差异。ⅧR:Ag、AT-Ⅲ与尿素氮（BUN）、血浆白蛋白（A1b）呈正相关，Fbg、PAgT与A1b呈负相关。结论 RNS存在严重的高凝状态。
Objective To investigate the changes of hemagglutination index in patients with refractory nephrotic syndrome (RNS). Methods 31 cases of RNS for the experimental group, another 31 cases of normal control. The levels of ⅧR: Ag, Fbg, AT-Ⅲ, Plg, APTT ), Prothrombin time (PT) and platelet aggregation test (PAgT) changes. Results: The expressions of ⅧR: Ag, Fbg and PAgT were significantly increased compared with the normal group. The levels of AT-Ⅲ and Plg were significantly decreased compared with the normal group, and the APTT time was significantly shortened. There was no significant difference between PT and the normal control group. ⅧR: Ag, AT-Ⅲ was positively correlated with urea nitrogen (BUN), plasma albumin (A1b), Fbg, PAgT was negatively correlated with A1b. Conclusion RNS has severe hypercoagulable state.