论文部分内容阅读
目的了解镇江市2015年手足口病的病原学和流行特征,为手足口病防治提供科学依据。方法采集镇江市临床诊断为手足口病患者的粪便或肛拭子样本,应用实时荧光定量PCR法进行肠道病毒及EV71、Cox A16特异性核酸检测。结果 2015年共检测373份样本,检出肠道病毒阳性样本97份,总阳性率为26.01%,其中EV71阳性19例,阳性率为5.09%;Cox A16阳性30例,阳性率为8.04%;其他肠道病毒阳性48例,阳性率为12.87%。男性人群手足口病发病率高于女性。5月和6月肠道病毒的阳性率最高,分别为46.43%和48.48%。78.82%(294/373)的标本源于5岁以下儿童,阳性率为26.87%。结论 2015年镇江市手足口病主要由其他肠道病毒引起,进一步深入开展流行病学和病原学研究,也将为手足口病的防治工作提供更加有力的依据。
Objective To understand the etiology and epidemiology of hand-foot-mouth disease in Zhenjiang in 2015, and to provide a scientific basis for the prevention and treatment of hand-foot-mouth disease. Methods Samples of feces or anal swab clinically diagnosed as hand-foot-mouth disease in Zhenjiang were collected. Real-time fluorescence quantitative PCR was used to detect enterovirus and EV71, Cox A16 specific nucleic acids. Results A total of 373 positive samples were detected in 2015, with a total positive rate of 26.01%, of which 19 were positive for EV71, the positive rate was 5.09%. The positive rate of Cox A16 was 30% (positive rate was 8.04%). 48 cases of other enterovirus positive, the positive rate was 12.87%. The incidence of hand-foot-mouth disease is higher in men than in women. The positive rates of enterovirus in May and June were the highest, 46.43% and 48.48% respectively. 78.82% (294/373) of the samples originated from children under 5 years old, the positive rate was 26.87%. Conclusion Hand-foot-mouth disease in Zhenjiang City in 2015 is mainly caused by other enteroviruses. Further study on epidemiology and etiology will be provided, which will provide a more powerful basis for the prevention and treatment of hand-foot-mouth disease.