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目的:观察中药对原发性肝癌肝动脉栓塞化疗(TACE)后患者发热及其CRP的影响。方法:选择2011年9月~2013年9月我院收治的原发性肝癌TACE术后且出现发热的患者75例,将其随机分为观察组39例,对照组36例,对照组术后常规处理,观察组术后联合中药治疗,比较两组患者发热临床疗效、不同时间点血清CRP水平以及治疗前后Karnofsky评分。结果:观察组发热治疗总有效率为94.87%,对照组发热治疗总有效率为75.00%,两组比较,差异具有统计学意义(P<0.05);术前以及术后3天两组患者血清CRP水平无统计学差异(P>0.05),而术后7天、术后14天,观察组患者血清CRP显著低于对照组(P<0.05)。结论:中药对原发性肝癌TACE术后发热患者具有显著的临床疗效,且能够有效抑制术后患者血清CRP水平的升高,表明其作用机制可能与抑制机体炎症反应有关。
Objective: To observe the effect of traditional Chinese medicine (TCM) on fever and CRP in patients with primary hepatocellular carcinoma after transcatheter arterial chemoembolization (TACE). Methods: From September 2011 to September 2013, 75 patients with primary hepatocellular carcinoma (HCC) who developed fever after TACE were randomly divided into observation group (n = 39) and control group (n = 36) The patients in the observation group were treated with traditional Chinese medicine after operation. The clinical efficacy of fever, the level of CRP at different time points and Karnofsky score before and after treatment were compared. Results: The total effective rate of fever in the observation group was 94.87%, and the total effective rate of fever in the control group was 75.00%. There was significant difference between the two groups (P <0.05). The serum of the two groups before and 3 days after operation There was no significant difference in CRP level between the two groups (P> 0.05). However, the CRP level of the observation group was significantly lower than that of the control group at 7 days and 14 days after operation (P <0.05). Conclusion: Traditional Chinese medicine has significant clinical curative effect on patients with primary hepatic carcinoma with fever after TACE, and can effectively inhibit the increase of serum CRP level in patients with postoperative hepatocellular carcinoma, indicating that its mechanism of action may be related to inhibiting the inflammatory reaction of the body.