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在出生前和出生后,神经系统的正常分化需要甲状腺激素,性激素及其它激素的调节。在神经系统发育的关键时期,上述任何一种激素不足,均可导致脑发育障碍。克汀病患者性腺发育不良,提示甲状腺激素可能影响性腺发育及性激素水平。本实验用丙基硫脲嘧啶诱导大鼠甲低,在其脑发育的临界期观察血浆雌二醇水平及3,5,3′-三碘甲腺原氨酸(T_3)对血浆雌二醇水平的影响。
Before birth and after birth, the normal differentiation of the nervous system requires the regulation of thyroid hormones, sex hormones and other hormones. In the critical period of nervous system development, any one of the above hormones, can lead to brain development disorders. Cretinism in patients with gonadal dysplasia, suggesting that thyroid hormone may affect gonadal development and sex hormone levels. In this experiment, propylthiouracil was used to induce hypothyroidism in rats. The plasma estradiol level and the effect of 3,5,3’-triiodothyronine (T_3) on plasma estradiol Horizontal impact.