人类基因的特异性探针可以从基因组的水平上研究遗传性或获得性基因的异常。人类抗体基因的研究更使人感兴趣,因为很多白血病及免疫缺失性疾病中有多种基因关系的表达。正常成年人有五类Ig,即IgM、IgG、IgD、IgE及IgA,亚类为IgG1～IgG4及IgA1～IgA2。这些免疫球蛋白含γ1、γ2、γ3、γ4及α1、α2重链恒定区(C_H)。 Specific probes for human genes can study inherited or acquired genetic abnormalities at the genome level. The study of human antibody genes is even more interesting, because many leukemia and immunodeficiency diseases have multiple gene-expression relationships. Normal adults have five types of Ig, that is, IgM, IgG, IgD, IgE and IgA, subclasses of IgG1 ~ IgG4 and IgA1 ~ IgA2. These immunoglobulins contain γ1, γ2, γ3, γ4 and α1, α2 heavy chain constant regions (C_H).