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目的 观察亚低温联合纳洛酮治疗脑出血的临床疗效及对血浆神经肽Y(NPY)、β-内啡肽(β-EP)的影响。方法 将我院1999年6月～2003年4月住院的98例急性脑出血病人随机分成两组,两组综合治疗相同,治疗组加用亚低温联合纳洛酮治疗:治疗前后分别采取空腹静脉血2 ml,用放免法检测NPY、β-EP的含量,同时对病人的神经功能缺损进行评分,评价临床疗效。结果 (1)治疗组总有效率91.7％,对照组总有效率64％,治疗组的有效率明显高于对照组(P<0.01);(2)急性期两组病人血浆NPY、β-内啡肽均升高,治疗后NPY、β-EP含量均下降,治疗组下降更为明显(P<0.01)。结论 亚低温联合纳洛酮治疗可以明显改善脑出血病人神经功能及预后,早期应用效果好。
Objective To observe the clinical efficacy of sub-hypothermia combined with naloxone on cerebral hemorrhage and its effect on plasma neuropeptide Y (NPY) and β-endorphin (β-EP). Methods A total of 98 patients with acute cerebral hemorrhage hospitalized from June 1999 to April 2003 in our hospital were randomly divided into two groups. The two groups were treated in the same way. The treatment group was treated with mild hypothermia combined with naloxone. Fasting venous Blood 2 ml, radioimmunoassay detection of NPY, β-EP content, while the patient’s neurological deficit score, evaluate the clinical efficacy. Results (1) The total effective rate was 91.7% in the treatment group and 64% in the control group. The effective rate in the treatment group was significantly higher than that in the control group (P <0.01). (2) The plasma NPY, (P <0.01). After treatment, the contents of NPY and β-EP decreased, the treatment group decreased more obviously (P <0.01). Conclusion Combined treatment of mild hypothermia and naloxone can significantly improve the neurological function and prognosis of patients with intracerebral hemorrhage.