The effects of optimized operation principles implemented at reservoirs on the Wujiang River in southwest China between September 2009 and April 2010 under drought conditions were analyzed based on operational data collected from the Guizhou Wujiang Hydropower Development Co., Ltd. A set of linear regression equations was developed to identify the key factors impacting the electric power generation at reservoirs. A 59% reduction in the inflow discharge at the Hongjiadu Reservoir led to a decrease of only 38% in the total electric power generation at the Hongjiadu, Dongfeng, Suofengying, and Wujiangdu reservoirs on the Wujiang River, indicating that optimized operation can play an important role in drought management. The water level and the amount of other water inputs at the Hongjiadu Reservoir and the outflow discharge at all of the reservoirs except the Wujiangdu Reservoir were key factors affecting the total electric power generation at reservoirs on the Wujiang River under optimized operation. The effects of optimizing operation principles implemented at reservoirs on the Wujiang River in southwest China between September 2009 and April 2010 under drought conditions were analyzed based on operational data collected from the Guizhou Wujiang Hydropower Development Co., Ltd. A set of linear regression equations was a 59% reduction in the inflow discharge at the Hongjiadu Reservoir led to a decrease of only 38% in the total electric power generation at the Hongjiadu, Dongfeng, Suofengying, and Wujiangdu reservoirs on the Wujiang River, indicating that an optimized operation can play an important role in drought management. The water level and the amount of other water inputs at the Hongjiadu Reservoir and the outflow discharge at all of the reservoirs except the Wujiangdu Reservoir were key factors affecting the total electric power generation at reservoirs on the Wujiang River under optimiz ed operation.