论文部分内容阅读
目的对比艾司奥美拉唑与奥美拉唑治疗幽门螺杆菌(Hp)相关性胃溃疡的疗效。方法选择2015年1月-2017年1月医院收治的Hp相关性胃溃疡患者94例,随机分为观察组和对照组各47例。观察组给予艾司奥美拉唑为主的Hp根除三联方案治疗,对照组给予奥美拉唑为主的Hp根除三联方案治疗,对比2组治疗效果、症状总积分、Hp根除与不良反应情况。结果观察组总有效率为95.7%显著高于对照组的74.5%,差异有统计学意义(χ2=9.928,P<0.05)。治疗前2组症状总积分对比无统计学差异(P>0.05);观察组治疗后2周和治疗后8周症状总积分均显著低于对照组,差异均有统计学意义(P<0.05)。治疗后观察组Hp根除率为95.7%(45/47)高于对照组的78.7%(37/47),差异有统计学意义(P<0.05);2组均未出现严重不良反应,2组不良反应发生率比较无统计学差异(P>0.05)。结论 Hp相关性胃溃疡患者采用艾司奥美拉唑治疗可有效改善患者临床症状,控制相关并发症的发生,疗效良好,值得临床推广采用。
Objective To compare the efficacy of esomeprazole and omeprazole in the treatment of Helicobacter pylori (Hp) -related gastric ulcer. Methods Ninety-four patients with Hp-related gastric ulcer admitted from January 2015 to January 2017 in our hospital were randomly divided into observation group (47 cases) and control group (47 cases). The observation group was treated with esomeprazole-based Hp eradication triple therapy, the control group was given omeprazole-based Hp eradication triple therapy, the treatment effect, total symptom score, Hp eradication and adverse reactions . Results The total effective rate in observation group was 95.7%, which was significantly higher than 74.5% in control group (χ2 = 9.928, P <0.05). There was no significant difference in the total scores of symptoms between the two groups before treatment (P> 0.05). The total scores of symptoms in the observation group at 2 weeks and 8 weeks after treatment were significantly lower than those in the control group (P <0.05) . After treatment, the Hp eradication rate in the observation group was 95.7% (45/47), which was significantly higher than that in the control group (78.7%, 37/47) (P <0.05). No serious adverse reactions were observed in the two groups. The incidence of adverse reactions was no significant difference (P> 0.05). Conclusion Esophageal injection of esomeprazole in patients with Hp-related gastric ulcer can effectively improve the clinical symptoms and control the occurrence of complications, and has good curative effect and is worthy of clinical promotion.